Materials Transactions Online

Materials Transactions, Vol.57 No.12 (2016) pp.2072-2076
© 2016 The Japan Institute of Metals and Materials

Preparation of Antibacterial ZnO-CaO-P2O5-Nb2O5 Invert Glasses

Sungho Lee1, Hirotaka Uehara1, Anthony L. B. Maçon1, Hirotaka Maeda1, Akiko Obata1, Kyosuke Ueda2, Takayuki Narushima2 and Toshihiro Kasuga1

1Division of Advanced Ceramics, Graduate School of Engineering, Nagoya Institute of Technology, Nagoya 466-8555, Japan
2Department of Metallurgy, Materials Science and Materials Processing, Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan

ZnO-CaO-P2O5-Nb2O5 invert glasses, with ZnO substituted for CaO, were successfully prepared using a melt-quenching method. Their structures, dissolution behaviors, and antibacterial abilities were evaluated. Niobate switched its role of network former to modifier with increasing ZnO content, as Zn2+ ions preferentially coordinated with phosphate groups. In parallel, with increasing content of ZnO in the glasses, P-O-Zn bonds were formed, which crosslinked phosphate groups with ZnO acting as a network former. As a result, the glass-forming ability and chemical durability of the glasses were improved. The glasses showed antibacterial ability to gram-positive and -negative bacteria.


(Received 2016/03/29; Accepted 2016/06/09; Published 2016/11/25)

Keywords: biomaterial, phosphate glass, zinc, niobium, antibacterial ability

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  1. A. Gristina: Science 237 (1987) 1588-1595.
  2. R.O. Darouiche: Clin. Infect. Dis. 33 (2001) 1567-1572.
  3. H.J. Busscher, H.C. van der Mei, G. Subbiahdoss, P.C. Jutte, J.J.A.M. van den Dungen, S.A.J. Zaat, M.J. Schultz and D.W. Grainger: Sci. Transl. Med. 4 (2012) 153rv10.
  4. P.A. Norowski and J.D. Bumgardner: J. Biomed. Mater. Res. B Appl. Biomater. 88B (2009) 530-543.
  5. D. Campoccia, L. Montanaro and C.R. Arciola: Biomaterials 34 (2013) 8018-8029.
  6. D. Campoccia, L. Montanaro and C.R. Arciola: Biomaterials 34 (2013) 8533-8554.
  7. T.N. Kim, Q.L. Feng, J.O. Kim, J. Wu, H. Wang, G.C. Chen and F.Z. Cui: J. Mater. Sci. Mater. Med. 9 (1998) 129-134.
  8. J.M. Schierholz, L.J. Lucas, A. Rump and G. Pulverer: J. Hosp. Infect. 40 (1998) 257-262.
  9. S. Jaiswal, P. McHale and B. Duffy: Colloids Surf. B Biointerfaces 94 (2012) 170-176.
  10. S. Atmaca, K. Gül and R. Çiçek: Turk. J. Med. Sci. 28 (1998) 595-597.
  11. T.N. Phan, T. Buckner, J. Sheng, J.D. Baldeck and R.E. Marquis: Oral Microbiol. Immunol. 19 (2004) 31-38.
  12. G.J. Harrap, J.S. Best and C.A. Saxton: Arch. Oral Biol. 29 (1984) 87-91.
  13. A. Yamamoto, R. Honma and M. Sumita: J. Biomed. Mater. Res. 39 (1998) 331-340.
  14. H. Maeda, S. Lee, T. Miyajima, A. Obata, K. Ueda, T. Narushima and T. Kasuga: J. Non-Cryst. Solids 432 Part A (2016) 60-64.
  15. S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima and T. Kasuga: J. Non-Cryst. Solids 426 (2015) 35-42.
  16. I. Mazali, L. Barbosa and O. Alves: J. Mater. Sci. 39 (2004) 1987-1995.
  17. A. Obata, Y. Takahashi, T. Miyajima, K. Ueda, T. Narushima and T. Kasuga: ACS Appl. Mater. Interfaces 4 (2012) 5684-5690.
  18. T. Narushima, K. Ueda, T. Goto, H. Masumoto, T. Katsube, H. Kawamura, C. Ouchi and Y. Iguchi: Mater. Trans. 46 (2005) 2246-2252.
  19. K. Ueda, T. Narushima, T. Goto, T. Katsube, H. Nakagawa, H. Kawamura and M. Taira: Mater. Trans. 48 (2007) 307-312.
  20. K. Ueda, T. Narushima, T. Goto, M. Taira and T. Katsube: Biomed. Mater. 2 (2007) S160-S166.
  21. M. Ouchetto, B. Elouadi and S. Parke: Phys. Chem. Glasses 32 (1991) 22-28.
  22. T. Kokubo and H. Takadama: Biomaterials 27 (2006) 2907-2915.
  23. A. Dietzel: Ztschr. Elektrochem 48 (1942) 9-23.
  24. R.K. Brow, D.R. Tallant, S.T. Myers and C.C. Phifer: J. Non-Cryst. Solids 191 (1995) 45-55.
  25. L. Montagne, G. Palavit and R. Delaval: J. Non-Cryst. Solids 215 (1997) 1-10.
  26. M.A. Karakassides, A. Saranti and I. Koutselas: J. Non-Cryst. Solids 347 (2004) 69-79.
  27. A. Flambard, J.J. Videau, L. Delevoye, T. Cardinal, C. Labrugère, C.A. Rivero, M. Couzi and L. Montagne: J. Non-Cryst. Solids 354 (2008) 3540-3547.
  28. S.M. Hsu, J.J. Wu, S.W. Yung, T.S. Chin, T. Zhang, Y.M. Lee, C.M. Chu and J.Y. Ding: J. Non-Cryst. Solids 358 (2012) 14-19.
  29. J.M. Jehng and I.E. Wachs: Chem. Mater. 3 (1991) 100-107.
  30. C.M. Chu, J.J. Wu, S.W. Yung, T.S. Chin, T. Zhang and F.B. Wu: J. Non-Cryst. Solids 357 (2011) 939-945.
  31. A. Mandlule, F. Döhler, L. van Wüllen, T. Kasuga and D.S. Brauer: J. Non-Cryst. Solids 392-393 (2014) 31-38.
  32. R.K. Brow: J. Non-Cryst. Solids 263-264 (2000) 1-28.
  33. S. Chenu, U. Werner-Zwanziger, C. Calahoo and J.W. Zwanziger: J. Non-Cryst. Solids 358 (2012) 1795-1805.


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